This blog post is purely for my own reference, but I have tried to find this information for about a week and decided that I could do myself a favor, and possibly the world, to put it somewhere accessible.
When setting up IBM Notes, one of the best settings you can make is to establish a managed replica of your mail so that you are working locally but mail is essentially pushed to your computer when it arrives.
Add these settings to your NOTES.INI or Notes Preferences on a Mac:
CacheMail=3 OutgoingMailSendThreshold=1 ReplicateOnNewMail=1
The first value creates the managed replica if a local replica does not already exist.
The second value means every time a new message is deposited in the local mailbox it will immediately be sent to the server.
The last value forces Notes to replicate new mail from the server every time we detect new mail has been delivered. This is crucial in keeping the cache “up to date”.